Contrast Media in Children 48 13. Clinical procedure - extravasation management - vesicants using dimethyl sulfoxide solution. Wall chart. For definitions of different categories of extravasation hazard and the details on management of extravasation, see BC Cancer Systemic Therapy Policy III-20 . R 1 Hurst S, McMillan M. Innovative solutions in critical care units: extravasation guidelines. Extravasation injury follows leakage of drugs or intravenous fluids from the veins or inadvertent administration into the subcutaneous or subdermal tissue. Consult the individual management chart for specific treatments, and/or the National Extravasation Information Service on 0121-554-3801 bleep. Gastroenterology. Prevention of these iatrogenic injuries is essential, however if an extravasation occurs early recognition and proper treatment are important in minimizing morbidity. : Ackermann, Monique, et al. Severe extravasation injuries can prolong hospitalization and increase costs. Philadelphia, PA: Children’s Oncology Group, 2007. Prevention and management of extravasation injuries in neonates. The medical team should be notified immediately and treatment must be individualized to each patient. Results in blistering and tissue necrosis and requires immediate attention to limit further injury. clinical guideline for neonatal intravenous extravasation injury: prevention and treatment download Report Hospital . Any medications that were used for the treatment of pre-existing heart failure are re-started as soon as clinically reasonable and re-titrated to achieve the best control of fluid balance and blood pressure Kanagasundaram S, Ashley C, Bhojani S, et al. The pebc produces evidence-based and evidence-informed guidelines, known as Evidence-Based Series … Labetalol 10–20 mg IV over 1–2 min, may repeat 1 time; or. Policy, procedure and practice guideline development. 2) References, National Professional Organizations, etc. Recommendations regarding the treatment of anti-cancer extravasation are based on animal models, case reports and a limited number of small uncontrolled studies, and are often conflicting. 14. Treatment decisions for individual patients require the weighing of a multiplicity of factors, which cannot all be accounted for in a clinical guideline. : Ackermann, Monique, et al. eviQ has reviewed all the available literature and attempted to provide some guidance in this area. August 2006. 3007 or Goldensoft. 7. 4.6 Assessment of moisture associated incontinence dermatitis (MAID) shall be with the Moisture Associated Incontinence Dermatitis Skin Care Guide (see Appendix H). Outside of oncology practice, there is no list of noncytotoxic vesicants established by a professional organization. The pebc ’s mandate is to improve the lives of Ontarians affected by cancer through the development, dissemination, and evaluation of evidence-based products designed to facilitate clinical, planning, and policy decisions about cancer care. > To educate staff on early preventative measures to reduce However, as in any clinical situation, there may be factors which cannot be covered by a single set of guidelines. undiagnosed or inappropriately treated can lead to necrosis, secondary infection and functional loss of the tissue and/or limb concerned. Guidelines for the treatment of extravasation injuries facilitate decision making, given their time-sensitive nature. Scope 17. Monitoring: IV site hourly for signs of extravasation due to the hyperosmolality of the infusion (see Insertion and management of peripheral and central venous access devices (QH only) An infrequent, but potential complication of chemotherapy is vesicant chemotherapy extravasation. 2. Classify the agent using the tables below and treat as directed (if not listed below consult Pharmacy) 3. 1.1. Treatment of Infiltrated Vesicant or Irritant Drugs. Guidelines on treatment of extravasation Filename: Extravasation PAGE:1 of 14 Date agreed: April 2018 Issue date: April 2018 Version: 5.0 Agreed by Chair Network Chemotherapy Group Review date: April 2020 with cytotoxic drugs We would like to thank European Oncology Nurses Society guidelines formed a major basis for developing this document. 1.3.1 Guideline for the Management of Extravasation of Chemotherapeutic Agents – Adult/Pediatric – Inpatient/Ambulatory Clinical Practice Guideline 1.3.2 Guideline for Non-chemotherapeutic Agents: Prevention and Treatment of Chemical Phlebitis and Extravasation of Peripherally Administered Non-chemotherapeutic Agents – Adult and The purpose of this document is to guide staff in the prevention, early detection and management of extravasation injuries in the neonatal/ infant population. Refer to Extravasation of Chemotherapy Agents Clinical Guideline Definition of terms. Policy on the Management of Extravasation, Network Site Specific Group 2016. All but one of the included studies were case series and the one before-and-after study24 primarily examined the effect of new extravasation treatment guidelines on knowledge of hyaluronidase, extravasation incident reporting and time from extravasation discovery to treatment. 1. This guideline is applicable to all levels of nursing, midwifery and medical staff caring for neonates and infants in the West of Scotland. Treatment of the extravasation will involve the nurse administering the phentolamine intradermally around the site of the extravasation. 12. This document outlines guidelines for the rapid treatment of Systemic Anti-Cancer Therapy (SACT) extravasation injuries within Royal Cornwall Hospital Trust. The scarcity of evidence available makes it difficult to develop an optimal management scheme. Extravasation Hazard Table, BCCA 2019. Nicardipine 5 mg/h IV, titrate up by 2.5 mg/h every 5–15 min, maximum 15 mg/h; when … An extravasation occurs when there is accidental infiltration of a vesicant or chemotherapeutic drug into the surrounding IV site. Non-compliance with this guideline Most nurses will prefer that the phentolamine is divided into several syringes each with a 25 gauge needle on them so that the same needle will not have to be used to penetrate the skin more than once. *Follow guidelines and treat like a vesicant. This guideline has been developed for medical staff caring for premature infants in the West of Scotland. If an extravasation is suspected treatment must begin as soon as possible. This guideline recommends appropriate use of enteral sodium bicarbonate, intravenous sodium bicarbonate, leucovorin, and glucarpidase as preventative supportive care for and the treatment of high-dose methotrexate toxicity. Post -Contrast Acute Kidney Injury and Contrast-Induced Nephropathy in Adults 33 11. 10. Local guidelines for the management of extravasation should be followed where they exist or specialist advice sought. Early detection and starting treatment within 24 hours can significantly reduce tissue damage. It can also occur in MRI studies, but the complications are rare given the low volumes that are used. As recommended in the 2005 AUA guideline on the Management of Staghorn Calculi, PCNL should also be the first treatment utilized for most patients with staghorn calculi. In 2007, the European Oncology Nursing Society published guidelines for extravasation prevention, detection, and management. In this case, infiltration and extravasation injury were probably related to azithromycin. Royal Alexandra Hospital, Edmonton. Ward 1B (Outpatient Dept) treatment room clinic 1; 6.2 The flowchart in the WOSCAN extravasation folder should be followed for the specific drug being administered (you must refer to the latest list on the WOSCAN website via the WOSCAN SACT Extravasation in Practice interactive pdf document). 7. Contrast Media Warming 29 10. Clinical procedure - extravasation management - … The purpose of this guideline is to provide clear guidance on the causes, prevention, recognition and management of an extravasation of a Systemic Anti-Cancer Therapy used in the treatment of malignant disease in the patient over the age of 16 who is being cared for in adult services. Diagnosis and use of urine markers is discussed in addition to variant histologies, resection, intravesical therapy, BCG therapy, cystectomy, enhanced cystoscopy, and patient follow up. Nurses need to be aware of current evidence-based guidelines for detecting and managing vesicant extravasations and need to be prepared to administer evidence-based treatment. According to the Oncology Nursing Society s Chemotherapy and Biotherapy Guidelines and Recommendations for Practice, treatments using sodium thiosulfite and DMSO have shown very limited success. r eviQ has reviewed all the available literature and attempted to provide some guidance in this area. Renal Mass and Localized Renal Cancer: AUA Guideline focuses on the evaluation and management of clinically localized renal masses suspicious for renal cell carcinoma (RCC). 2018 Mar. Management of the extravasation of anti-neoplastic agents. 2019 WSES guidelines for the management of severe acute pancreatitis. Ward 1B (Outpatient Dept) treatment room clinic 1; 6.2 The flowchart in the WOSCAN extravasation folder should be followed for the specific drug being administered (you must refer to the latest list on the WOSCAN website via the WOSCAN SACT Extravasation in Practice interactive pdf document). Extravasation - inadvertent administration of a vesicant into the surrounding tissue instead of the intended intravenous pathway. It causes pain, erythema, inflammation, discomfort and if left. It must be emphasised that clinical guidelines present the best evidence available to the experts but following guideline recommendations will not necessarily result in the best outcome. Guideline No: 1/C/16:9057-01:00 Guideline: IV Extravasation Management This document reflects what is currently regarded as safe practice. Serious adverse effects associated with hyaluronidase treatment (anaphylaxis or angioedema) are rare, reported in fewer than 1% of patients. 9 results. Metoprolol Cold Hydrocortisone 50-200 mg Give via 5-10 SQ or TD injections into area of extravasation Medication Thermal Therapy Antidote Dose Treatment Nitroglycerin Cold Hydrocortisone 50-200 mg Give via 5-10 SQ or TD injections into area of extravasation Norepinephrine Heat Nitroglycerin 2% paste n/a Apply thin layer to area of extravasation q 6 hr x 24 hr Extravasation is the process by which any liquid (fluid or drug) accidentally leaks into the surrounding tissue. These guidelines are the first regional acute oncology guidelines in Northern Ireland and will give a consistent and equitable approach to patient … 11. This guideline provides recommendations for … Appendix A Extravasation work flow algorithm non-chemotherapy. This document does not replace the need for the Document extravasation and management in the patient’s electronic health record. GUIDELINE FOR MANAGEMENT OF EXTRAVASATION. Extravasation: the unintentional leakage of vesicant fluids or medications from the vein into the surrounding tissue Diagnosis, patient counseling, and renal biopsy are covered in addition to various management strategies, including partial and radical nephrectomy, thermal ablation, and active surveillance. extravasation guidelines (EONS 2007) DEFINITION Extravasation is the inadvertent administration of vesicant drugs into surrounding tissues, which can lead to tissue necrosis, while infiltration is the inadvertent administration of non-vesicant solutions/medications into the surrounding tissues (Weinstein 2007; RCN 2010). ; Cerebral oedema is a rare but serious complication requiring urgent treatment and critical care. There is currently a paucity of literature on the principles of management of extravasation injuries, with no clear guidelines with respect to validated treatment recommendations for TPN extravasation… Summary of Guideline Development Methods. extravasation, may result in patient injuries that range from prolonged length of stay, rehospitalization, and long-term treatment requirements to permanent functional impairment and even loss of limb. Extravasation injury from cancer chemotherapy is reported to be 11% in children and 22% in adults.3 Jacobs reported a rate of 0.6% (41 events out of 6,600 injections) for extravasation of contrast agents given with high-pressure injector pumps.4 Although pumps do not cause infiltration or extravasation, their use forces fluid into the subcuta- In 2007, the European Oncology Nursing Society published guidelines for extravasation prevention, detection, and management. Extravasation is a well-recognised and serious complication of any intravenous therapies but especially chemotherapeutic agents. Extravasation and Infiltration Injuries - management in PICU. An infrequent, but potential complication of chemotherapy is vesicant chemotherapy extravasation. Contrast media extravasation (CMEV) refers to the leakage of intravenously-administered contrast media from the normal intravascular compartment into surrounding soft tissues; it is a well-known complication of contrast-enhanced CT scanning. Identification and treatment of extravasation injury in neonates and children In accordance with best practice guidance for extravasation injury management in neonates and children This guideline applies to all clinical staff working in the Neonatal and Paediatric wards and must be adhered to. Extravasation. [Guideline] Leppäniemi A, Tolonen M, Tarasconi A, et al. Worcester: Worcestershire Acute Hospitals NHS Trust; 2015. Chemotherapy extravasation guideline WOSCAN September 2009 page 3 Introduction Aims of this guideline > To provide evidence-based guidance or best practice in the absence of evidence, on all aspects of extravasation to promote a consistent approach across the West of Scotland. Guideline for the management of extravasation of a cytotoxic agent or a monoclonal antibody used in the treatment of malignant disease: version 4.2. In the absence of national Methods— A formal literature search of PubMed was performed through the end of August 2013. 7. It provides a guideline to assist practitioners in the care of patients who may have experienced an extravasation injury as a result of SACT. The Clinical Guidelines provide a description of the range of treatment options available for a clinical scenario. The Prostate Cancer (PCa) Guidelines Panel have prepared this guidelines document to assist medical professionals in the evidence-based management of PCa. The ESMO Clinical Practice Guidelines (CPG) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings of evidence-based medicine.. Latest enhanced and revised set of guidelines. Extravasation is an Newborn Critical Care Center (NCCC) Clinical Guidelines Evaluation and Treatment of IV Infiltration or Extravasation GOAL Safely administer intravenous fluids/medications with minimal complications. 13. Extravasation is a severe complication in the administration of cytotoxic chemotherapy. 13–15 Chiew at al have demonstrated that guideline adherence is lowest in chemoradiation (47%) for the advanced stage. A study with … Clinical Guideline - Extravasation Injury Treatment, November 2001. the provision of treatment. This document outlines guidelines for the rapid treatment of Systemic Anti-Cancer Therapy (SACT) extravasation injuries within Royal Cornwall Hospital Trust. Authors Dr Judith Carser Consultant Medical Oncologist SHSCT The recommendations in this guide are meant to serve as treatment guidelines for use at Michigan Medicine facilities. The extravasation risk is 2-5% with few patients requiring antidote administration or surgical intervention. Incidence. Ramasethu J. It usually causes a Initial medical treatment of acute pancreatitis: American Gastroenterological Association Institute Technical Review. Monitor BP continuously if possible, or 5 minutely for 1 hour after administration. Contrast Extravasation Guidelines: [Iodine and Gadolinium] Extravasation of contrast medium is toxic to the surrounding tissue, particularly the skin, and can produce an acute inflammatory response. 2019. Dimensions Critical Care Nursing 2004; 23(3): 125-8. Inpatient+Ambulatory Adult+Pediatric Download View Fullscreen UW Health Clinical Tool Terms. Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline provides a risk-stratified clinical framework for the management of non-muscle invasive bladder cancer. current standard of care, state-of-the-art, or best practices for a particular practice guideline, dosage or other agent guidel ine, disease, condition, or treatment. Clinical Guideline - Extravasation Injury Treatment, November 2001. For neonatal extravasation refer to RCH guideline Neonatal Extravasation Plastics team to review the patient Document the date and time of the infusion when extravasation was noted, the type and size of catheter, the drug administered, the estimated amount of … Immunotherapy extravasation’s management is not considered in the available oncological guidelines. Supportive and palliative care are areas of high importance in oncology and ESMO published Clinical Practice Guidelines on the management … Extravasation is an oncology emergency and therefore Elevating the extremity and the use of either warm or cold compresses can be quite beneficial as comfort measures, but controlled studies 3. Extravasation is not as rare as many people think, and it may occur even in the most closely monitored situations. Treatment includes administration of 100% oxygen and placing the patient in a left lateral decubitus position. Intravenous Extravastion in Neonates. This clinical guideline on Urotrama discusses diagnosis and management of genitourinary injuries, including renal, ureteral, bladder, urethral, and genital trauma. This guideline does not address the extravasation of chemotherapeutic agents. It provides a guideline to assist practitioners in the care of patients who may have experienced an extravasation injury as a result of SACT. The best treatment for extravasation is prevention. The guideline for the management of hypochlorite extrusion injuries has divided treatment in two modalities; Relative to severity of injury Relative to … The aim of this guideline is to present current and comprehensive recommendations for the diagnosis and treatment of spontaneous intracerebral hemorrhage. Extravasation is an Published 2014; Amended 2017, 2020. Extravasation Injury Staging Tool (see Appendix G). Extravasation of doxorubicin can result in severe local tissue injury manifesting as blistering, ulceration, and necrosis requiring wide excision of the affected area and skin grafting. Irritants can result in pain at the IV site and along the vein and may or may not cause inflammation. Women who are clinically stable will be allocated an appointment for the Infusion Unit (usually Tuesday and Thursday’s). **Some case reports of extravasation and injection site reactions or inflammation have been reported. Management of chemotherapy extravasation: ESMO--EONS clinical practice guidelines. When the extravasation occurs, commonly used antidotes may or may not work. Urinary extravasation occurs in ~30% of patients with high-grade renal trauma, but the lack of evidence-based guidelines complicates its clinical management. Guideline for Non-chemotherapeutic agents: Prevention and Treatment of Chemical Phlebitis and Extravasation of Peripherally Administered Non-chemotherapeutic Agents High Alert Medication Administration UWHC Guidelines for IV Administration of Formulary Medications in Adults. J Urol 2014, 192: 327. This guideline updates and replaces NICE guideline CG149 (August 2012), which was called neonatal infection: (early onset): antibiotics for prevention and treatment. It usually causes a The purpose of this guideline is to review the relevant scientific literature on the prevention, management, and treatment of extravasation occurring during the administration of … J Pharm Technol 2005;21:83-6. Epirubicin is an anthracycline chemotherapy agent used for treatment of several cancers including oesophageal, breast and gastric. However, in some cases extravasation may only become apparent 1-4 weeks after administration. Clinical practice guidelines provide evidence-based symptom management recommendations for patient care. Philadelphia, PA: Children’s Oncology Group, 2007. Prevention and management of extravasation injuries in neonates. Paediatric Peripheral Extravasation Treatment Guideline Peripheral Extravasation Injury Extravasation is the inadvertent leakage of IV fluids/medications from the intravascular to interstitial space, which has the potential to result in local tissue necrosis. Potentially fatal metabolic disorder. This study is aimed to evaluate the effectiveness of an evidence-based clinical practice guideline in the prevention and management of neonatal extravasation injury, and to examine the change in nurses' knowledge of and adherence to the guideline. Risk factors for tissue ischemia include pre-existing vasculopathy, hypotension, diabetic neuropathy, Raynaud disease, advanced age and volume of vasopressor infiltrated. NICaN Acute Oncology Clinical Guidelines (PDF) Published by Northern Ireland Cancer Network, 15 December 2015. Venous hypertension as a … If dehydrated, commence maintenance fluids plus replacement of deficit over 24 hours. Appropriate immediate management may reduce further damage, limb loss, and even avoid potential litigation. World J Emerg Surg. Key points DKA. Vasopressor extravasation can cause tissue ischemia and necrosis. The purpose of this guideline is to provide clear guidance on the causes, prevention, recognition and management of an extravasation of a systemic anticancer therapy used in the treatment of malignant disease in the patient over the age of 16 who is being cared for in adult services. Adverse Reactions (Preferred Term) HDD-CKD NDD-CKD PDD-CKD. Neonatal outcomes, including the rates of peripheral intravenous extravasation and extravasation from a central line, were collected at the pre- and post-intervention periods. Guidelines incorporate published research with expert consensus on the certainty of the evidence, the balance of benefits and harms and patient preferences and values. The clinical practice guideline was developed, and a multifaceted educational program was delivered to nurses. Vesicants have the potential to cause blistering and ulceration when they extravasate from the vein or are inadvertently administered into the tissue. necrosis, resulting in scarring and/or reduced function of the involved extremity. Elevating the extremity and the use of either warm or cold compresses can be quite beneficial as comfort measures, but controlled studies INFILTRATION AND EXTRAVASATION - GUIDELINES FOR ANTIDOTE ADMINISTRATION POLICY STATEMENTS Peripheral intravenous sites are not recommended for infusions of vesicant agents but may be used for direct IV injections and intermittent infusions, in which case the peripheral IV site must be visualized continuously throughout the infusion. The purpose of this document is to guide staff in the prevention, early detection and management of extravasation injuries in the neonatal/ infant population. 2) References, National Professional Organizations, etc. Extravasation is not as rare as many people think, and it may occur even in the most closely monitored situations. Kingston General Hospital. However, when extravasation does occur, it is important to recognize and treat it promptly [3-5]. The aim is to provide standardised PDA assessment, the rationale behind different treatment approaches and drug dosing regimes for those considering pharmacological closure of the PDA. Joyce Generali, Dennis J Cada Nitroglycerin (Topical): Extravasation treatment, Hospital Pharmacy, Volume 36 No 10 pp 1091-1095 2001 Baserga m, Puri A and Sola A. Extravasation and Tissue Necrosis. Provide guidelines for providing care to adult patients who are receiving intravenous vasopressors through a peripheral venous line (PVL). When SCHN documents are developed (or reviewed) key SCHN stakeholders form multidisciplinary teams reviewing the latest literature and apply best practice, appropriate Legislation, NSW Ministry of Health Policy and Professional Standards. guideline (procedure) for the rapid treatment of extravasation injuries due to cytotoxic chemotherapy and any other drug capable of causing this type of injury. 14:27. . B. Most guidelines suggest compression with heat packs and subcutaneous hyaluronidase injections [2, 4, 6]. Allergic -Like And Physiologic Reactions to Intravascular Iodinated Contrast Media 22 9. [3] Chemotherapy drugs are classified in vescicants, irritants and non-vescicants. Extravasation injury from vesicant/irritant drugs is best described with antineoplastic agents , but a number of other non-antineoplastic drugs can cause extravasation injury . Oxali must be diluted in dextrose, because it is chemically inactive in normal saline. 2. Support Care Cancer. ARIN Clinical Practice Guideline, Extravasation of Contrast Media, page 2 o There is no clear consensus regarding treatment for contrast medium extravasations. Immediate detection and treatment are critical to decrease morbidity associated with infiltration events. The recommendations from the COVID-19 Treatment Guidelines Panel (the Panel) are based on the results of these studies. The guidelines focus on important clinical decisions and actions in the context of overall case management. Venous ulcers are the most common type of chronic lower extremity ulcers, affecting 1% to 3% of the U.S. population. Elevation of the affected extremity above the level of the heart to … @article{Fidalgo2012ManagementOC, title={Management of chemotherapy extravasation: ESMO--EONS clinical practice guidelines. 154(4):1103-39. . The information provided on this site, including links to relevant websites and the information contained therein, is for use by health care providers and health care organizations only. 17. Use of animal Extravasation Guidelines. In the absence of national Boulanger J et al. Collect extravasation kit 4. 1.2. In March, the third edition of this guideline was published, including updated information on management of extravasations. Guide to extravasation management in adult patients. Extravasation. Recommendations regarding the treatment of anti-cancer agent extravasation are based on animal models, case reports and a limited number of small uncontrolled studies, and are often conflicting. Management of the extravasation of anti-neoplastic agents. In the event of an infiltration or extravasation, prompt and appropriate assessment and intervention will … E 2 The National Extravasation Information Service. Royal Alexandra Hospital, Edmonton. Venofer (N=231) % Venofer (N=139) % Oral Iron (N=139) % Venofer (N=75) % ≥ 2% of Study Populations and for which. ARIN Clinical Practice Guideline, Extravasation of Contrast Media, page 2 o There is no clear consensus regarding treatment for contrast medium extravasations. Extravasation Injuries Page 3 of 3 Neonatal Guideline Hypotension is the most noted side-effect. Furthermore, Savene (dexrazoxane) is the only registered drug for the treatment of antracycline extravasation. Remdesivir should be administered in a hospital or a health care setting that can provide a similar level of care to an inpatient hospital. STOP the injection immediately, but leave the cannula in place 2. Extravasation Guidelines. extravasation. Remdesivir has been studied in several clinical trials for the treatment of COVID-19. It can cause pain, swelling, erythema, tissue damage, blistering, sloughing, tis - sue necrosis, and signi cant morbidity that may require surgical interven- 16. The search terms used were vesicant extravasation, vesicant extravasation treatment, extravasation guidelines, and evidence-based practice. The purpose of this guideline is to provide clear guidance on the causes, prevention, recognition and management of an extravasation of a cytotoxic agent or a monoclonal antibody used in the treatment of malignant disease in the patient over the age of 16 who is being cared for in adult services. Refer to QCH IV Fluid Guideline (QH only). Regarding chemotherapy extravasation guidelines are very clear and detailed. Paediatric Peripheral Extravasation Treatment Guideline Peripheral Extravasation Injury Extravasation is the inadvertent leakage of IV fluids/medications from the intravascular to interstitial space, which has the potential to result in local tissue necrosis. Guideline for Management of Extravasation, NHS East Midland, 2018. The recommendations in this guide are meant to serve as treatment guidelines for use at Michigan Medicine facilities. ONS Guidelines™. These guidelines and the accompanying materials are to assist Michigan Medicine physicians in providing optimal care for patients in a cost-effective manner. Treatment of Infiltrated Vesicant or Irritant Drugs. the Rate for Venofer Exceeds the Rate for Comparator. The use of topical nitroglycerin ointment to treat Clevidipine 1–2 mg/h IV, titrate by doubling the dose every 2–5 min until desired BP reached; maximum 21 mg/h; or.
Minimalist Fashion Book,
Oyster Happy Hour Cape Cod,
Varsity Tutors Act Question Of The Day,
Lake Placid Monarch Ice Skates,
Stem Healthcare Salary,